Anderson Lab
Division of Rheumatology, Immunology and Allergy
Brigham and Women's Hospital
One Jimmy Fund Way Smith Building
Boston, MA  02115  U.S.A


  Principal Investigator
Paul J. Anderson, M.D., Ph.D.
K. Frank Austen Professor of Medicine
Smith Building, Room 652
Tel: (617) 525-1202
Fax: (617) 525-1310
Email:
panderson@rics.bwh.harvard.edu

My current research activities are in the following areas: 1) post-transcriptional regulation of inflammatory cytokine production; 2) translational initiation; and 3) stress-induced autoimmunity. Work in my laboratory is focused on the post-transcriptional mechanisms that regulate the production of inflammatory mediators. In the clinical area, I have maintained an outpatient specialty clinic in rheumatology at the Brigham Arthritis Center since 1986. The case mix in the ambulatory center of the Brigham Arthritis Center consists of patients with a variety of rheumatic diseases including rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, scleroderma, and psoriatic arthritis. Over the past five years I have been a member of the Rheumatology Division Fellowship Selection Committee. This committee interviews all applicants for the Rheumatology Fellowship Program and makes recommendations for ranking these candidates.


  Faculty / Confocal Facility Director
Nancy Kedersha, Ph.D.

Instructor in Medicine
Smith Building, Room 633
Tel: (617) 525-121
Fax: (617) 525-1310
Email: nkedersha@rics.bwh.harvard.edu

Since 1997, I’ve focused on a novel subcellular mystery: stress-induced aggregates of mRNA, which we named “stress granules" or SGs. These dynamic cytoplasmic structures form when stress causes cells to put the brakes on protein translation and reprogram their translational repertoire, a post-transcriptional form of regulation we describe as mRNA triage. Phosphorylation of eIF2-alpha initiates SG assembly, but involve many proteins and components of the translational machinery. Major protein nucleators of SGs include 3 proteins discovered in this lab: TIA-1, TIAR, and FAST. The ongoing challenge is to determine how SG formation links mRNA metabolism to cell growth and survival.

Pasha Ivanov  

Faculty
Pavel Ivanov, Ph.D.

Instructor in Medicine
Smith Building, Room 608
Tel: (617) 525-1233
Fax: (617) 525-1310
Email: pivanov@rics.bwh.harvard.edu

My research activity is connected to the field of RNA and specifically to the post-transcriptional regulation of gene expression.

 


  Clinical and Research Fellow
in Rheumatology and Immunology

Rumey C. Ishizawr, M.D., Ph.D.
Smith Building, Room 608
Tel: (617) 525-1217
Fax: (617) 525-1310
Email:
rishizawar@partners.org
 

  Research Fellow
Mohamed Emara, Ph.D.
Smith Building, Room 608
Tel: (617) 525-1232
Fax: (617) 525-1310
Email: memara@rics.bwh.harvard.edu

 

  Research Fellow
Ken Fujimura, Ph.D.

Smith Building, Room 608
Tel: (617) 525-1210
Fax: (617) 525-1310
Email: kfujister@gmail.com

  Technician
Victoria Ivanova
, M.Sc.
Smith Building, Room 608
Tel: (617) 525-1233
Fax: (617) 525-1310
Email: vivanova@partners.org

 


  Technician
Daniele Sciaranghella

Smith Building, Room 608
Tel: (617) 525-1213
Fax: (617) 525-1310
Email:
dsciaranghella@partners.org
  Technician
Samantha Stewart

Smith Building, Room 608
Tel: (617) 525-1216
Fax: (617) 525-1310
Email: sstewart6@rics.bwh.harvard.edu

  Confocal Facility Manager
Julie Ducharme

Smith Building, Room 608
Tel: (617) 525-1214
Fax: (617) 525-1310
Email:
jducharme@partners.org

The Brigham and Women's Hospital Confocal Microscopy Core is located within the Division of Rheumatology, Immunology and Allergy, in the Smith Building.

Our facility provides equipment and training for researchers interested in using widefield & confocal microscopy, photobleaching, and live cell imaging studies.

Our facility is open to all, incuding BWH departments, Longwood Medical Area affiliates and industry. There is a required training session for new users.

Find out more information about the Confocal Facility: how to schedule appointments, hourly rates, instruction guides and protocols, links to reference sites for confocal users, at: http://confocal.bwh.harvard.edu/ .


  Administrative / WebSite
Anne R. Howson

Smith Building, Room 652
Tel: (617) 525-1200 (direct)
Fax: (617) 525-1310
Email: ahowson@rics.bwh.harvard.edu
 

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