Anderson
Lab |
|
Principal
Investigator Paul J. Anderson, M.D., Ph.D. K. Frank Austen Professor of Medicine Smith Building, Room 652 Tel: (617) 525-1202 Fax: (617) 525-1310 Email: panderson@rics.bwh.harvard.edu |
My current research activities are in the following areas: 1) post-transcriptional regulation of inflammatory cytokine production; 2) translational initiation; and 3) stress-induced autoimmunity. Work in my laboratory is focused on the post-transcriptional mechanisms that regulate the production of inflammatory mediators. In the clinical area, I have maintained an outpatient specialty clinic in rheumatology at the Brigham Arthritis Center since 1986. The case mix in the ambulatory center of the Brigham Arthritis Center consists of patients with a variety of rheumatic diseases including rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, scleroderma, and psoriatic arthritis. Over the past five years I have been a member of the Rheumatology Division Fellowship Selection Committee. This committee interviews all applicants for the Rheumatology Fellowship Program and makes recommendations for ranking these candidates. |
|
|
Faculty /
Confocal Facility Director Nancy Kedersha, Ph.D. Instructor in Medicine Smith Building, Room 633 Tel: (617) 525-121 Fax: (617) 525-1310 Email: nkedersha@rics.bwh.harvard.edu |
Since 1997, I’ve focused on a novel subcellular mystery: stress-induced aggregates of mRNA, which we named “stress granules" or SGs. These dynamic cytoplasmic structures form when stress causes cells to put the brakes on protein translation and reprogram their translational repertoire, a post-transcriptional form of regulation we describe as mRNA triage. Phosphorylation of eIF2-alpha initiates SG assembly, but involve many proteins and components of the translational machinery. Major protein nucleators of SGs include 3 proteins discovered in this lab: TIA-1, TIAR, and FAST. The ongoing challenge is to determine how SG formation links mRNA metabolism to cell growth and survival. | |
![]() |
Faculty |
My research activity is connected to the field of RNA and specifically to the post-transcriptional regulation of gene expression.
|
|
![]() |
Clinical
and Research Fellow in Rheumatology and Immunology Rumey C. Ishizawr, M.D., Ph.D. Smith Building, Room 608 Tel: (617) 525-1217 Fax: (617) 525-1310 Email: rishizawar@partners.org |
||
![]() |
Research
Fellow Mohamed Emara, Ph.D. Smith Building, Room 608 Tel: (617) 525-1232 Fax: (617) 525-1310 Email: memara@rics.bwh.harvard.edu |
||
![]() |
Research
Fellow Ken Fujimura, Ph.D. Smith Building, Room 608 Tel: (617) 525-1210 Fax: (617) 525-1310 Email: kfujister@gmail.com |
![]() |
Technician Victoria Ivanova, M.Sc. Smith Building, Room 608 Tel: (617) 525-1233 Fax: (617) 525-1310 Email: vivanova@partners.org |
||
![]() |
Technician Daniele Sciaranghella Smith Building, Room 608 Tel: (617) 525-1213 Fax: (617) 525-1310 Email: dsciaranghella@partners.org |
![]() |
Technician Samantha Stewart Smith Building, Room 608 Tel: (617) 525-1216 Fax: (617) 525-1310 Email: sstewart6@rics.bwh.harvard.edu |
||
![]() |
Confocal
Facility Manager Julie Ducharme Smith Building, Room 608 Tel: (617) 525-1214 Fax: (617) 525-1310 Email: jducharme@partners.org |
The Brigham and Women's Hospital Confocal Microscopy Core is located within the Division of Rheumatology, Immunology and Allergy, in the Smith Building. Our facility provides equipment and training for researchers interested in using widefield & confocal microscopy, photobleaching, and live cell imaging studies. Our facility is open to all, incuding BWH departments, Longwood Medical Area affiliates and industry. There is a required training session for new users. Find out more information about the Confocal Facility: how to schedule appointments, hourly rates, instruction guides and protocols, links to reference sites for confocal users, at: http://confocal.bwh.harvard.edu/ . |
|
![]() |
Administrative
/ WebSite Anne R. Howson Smith Building, Room 652 Tel: (617) 525-1200 (direct) Fax: (617) 525-1310 Email: ahowson@rics.bwh.harvard.edu |
||
| Home | Lab Members page |
|---|